| Tissue Specificity | Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. |
| Post Translational Modifications | The removal of the C-terminal lumenal domain occurs by proteolytic processing. |
| Function | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules.this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity. |
| Protein Name | Inositol 1 -4 -5-Triphosphate Receptor Associated 2Lymphoid-Restricted Membrane ProteinProtein Jaw1 Cleaved Into - Processed Inositol 1 -4 -5-Triphosphate Receptor Associated 2 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Processed Inositol 145-Triphosphate Receptor Associated 2: CytoplasmEndoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinNucleus EnvelopeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleChromosomeColocalized With Itpr3 On The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Triphosphate Receptor Associated 2 antibodyAnti-Lymphoid-Restricted Membrane Protein antibodyAnti-Protein Jaw1 Cleaved Into - Processed Inositol 1 -4 -5-Triphosphate Receptor Associated 2 antibodyAnti-IRAG2 antibodyAnti-JAW1 antibodyAnti-LRMP antibody |
Information sourced from Uniprot.org
