| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LAX1 |
| Gene ID: | 54900 |
| Uniprot ID: | LAX1_HUMAN |
| Immunogen Region: | 77-398 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
| Immunogen Sequence: | MPLLTLPQTRQRAKNIYDIL PWRQEDLGRHESRSMRIFST ESLLSRNSESPEHVPSQAGN AFQEHTAHIHATEYAVGIYD NAMVPQMCGNLTPSAHCINV RASRDCASISSEDSHDYVNV PTAEEIAETLASTKSPSRNL FVLPSTQKLEFTEERDEGCG DAGDCTSLYSPGAEDSDSLS NGEGSSQISNDYVNMTGLDL SAIQERQLWVAFQCCRDYEN VPAADPSGSQQQAEKDVPS |
| Tissue Specificity | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. |
| Post Translational Modifications | Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation.which leads to the recruitment of GRB2, PIK3R1 and GRAP2. |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
| Protein Name | Lymphocyte Transmembrane Adapter 1Linker For Activation Of X CellsMembrane-Associated Adapter Protein Lax |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Transmembrane Adapter 1 antibodyAnti-Linker For Activation Of X Cells antibodyAnti-Membrane-Associated Adapter Protein Lax antibodyAnti-LAX1 antibodyAnti-LAX antibody |
Information sourced from Uniprot.org