| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KSR2 (780-890) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KSR2 |
| Gene ID: |
283455 |
| Uniprot ID: |
KSR2_HUMAN |
| Immunogen Region: |
780-890 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 780-890 of human KSR2 (NP_775869.3). |
| Immunogen Sequence: |
ISGVLQAGRREDKLRIQNGW LCHLAPEIIRQLSPDTEEDK LPFSKHSDVFALGTIWYELH AREWPFKTQPAEAIIWQMGT GMKPNLSQIGMGKEISDILL FCWAFEQEERP |
| Tissue Specificity | Mainly expressed in brain and kidney. |
| Post Translational Modifications | Phosphorylated on Ser-474 by MARK3. |
| Function | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF.upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. |
| Protein Name | Kinase Suppressor Of Ras 2Hksr2 |
| Database Links | Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Kinase Suppressor Of Ras 2 antibodyAnti-Hksr2 antibodyAnti-KSR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
