| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KNSTRN (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KNSTRN |
| Gene ID: |
90417 |
| Uniprot ID: |
SKAP_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1). |
| Immunogen Sequence: |
MAAPEAPPLDRVFRTTWLST ECDSHPLPPSYRKFLFETQA ADLAGGTTVAAGNLLNESEK DCGQDRRAPGVQPCRLVTMT SVVKTVYSLQPPSALSGGQP ADTQTRATSKSLLPVRSKEV DVSKQLHSGGPENDVTKITK LRRENGQMKATDTATRRNVR KGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGEL KDLTQKVELLEKFRDNCLAI LESKGLDPALGSETLASRQ |
| Tissue Specificity | Widely expressed, including in skin. |
| Function | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19.however, these results need additional evidences. |
| Protein Name | Small Kinetochore-Associated ProteinSkapKinetochore-Localized Astrin-Binding ProteinKinastrinKinetochore-Localized Astrin/Spag5-Binding ProteinTraf4-Associated Factor 1 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindle PoleMicrotubule Organizing CenterColocalizes With Microtubules Around Centrosomes In Prophase And With The Mitotic Spindle At Prometaphase And MetaphaseFrom Late Prometaphase To AnaphaseIs Highly Concentrated On KinetochoresLocated At The Kinetochore-Microtubule InterfaceThe Astrin (Spag5)-Kinastrin (Skap) Complex Localizes To The Microtubule Plus Ends |
| Alternative Antibody Names | Anti-Small Kinetochore-Associated Protein antibodyAnti-Skap antibodyAnti-Kinetochore-Localized Astrin-Binding Protein antibodyAnti-Kinastrin antibodyAnti-Kinetochore-Localized Astrin/Spag5-Binding Protein antibodyAnti-Traf4-Associated Factor 1 antibodyAnti-KNSTRN antibodyAnti-C15orf23 antibodyAnti-SKAP antibodyAnti-TRAF4AF1 antibodyAnti-HSD11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
