| Tissue Specificity | Widely expressed, including in skin. |
| Function | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19.however, these results need additional evidences. |
| Protein Name | Small Kinetochore-Associated ProteinSkapKinetochore-Localized Astrin-Binding ProteinKinastrinKinetochore-Localized Astrin/Spag5-Binding ProteinTraf4-Associated Factor 1 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindle PoleMicrotubule Organizing CenterColocalizes With Microtubules Around Centrosomes In Prophase And With The Mitotic Spindle At Prometaphase And MetaphaseFrom Late Prometaphase To AnaphaseIs Highly Concentrated On KinetochoresLocated At The Kinetochore-Microtubule InterfaceThe Astrin (Spag5)-Kinastrin (Skap) Complex Localizes To The Microtubule Plus Ends |
| Alternative Antibody Names | Anti-Small Kinetochore-Associated Protein antibodyAnti-Skap antibodyAnti-Kinetochore-Localized Astrin-Binding Protein antibodyAnti-Kinastrin antibodyAnti-Kinetochore-Localized Astrin/Spag5-Binding Protein antibodyAnti-Traf4-Associated Factor 1 antibodyAnti-KNSTRN antibodyAnti-C15orf23 antibodyAnti-SKAP antibodyAnti-TRAF4AF1 antibodyAnti-HSD11 antibody |
Information sourced from Uniprot.org
