| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
KIZ |
| Gene ID: |
55857 |
| Uniprot ID: |
KIZ_HUMAN |
| Immunogen Region: |
1-240 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KIZ (NP_060944.3). |
| Immunogen Sequence: |
MSRTLASAVPLSSPDYYERL GQLQHGLRDSEKKRLDLEKK LYEYNQSDTCRVKLKYVKLK NYLKEICESEKKAHTRNQEY LKRFERVQAHVVHFTTNTEK LQKLKLEYETQIKKMLCSKD SLGLKEELTDEDREKVAVHE GINSGTAMSRGLYQPATIFM GRQMSAILSMRDFSTEHKSP QPTKNFSIPDPHSHRQTAQS SNVTDSCVVQTSNDTQCLNK SDNIDGKASLQIGEKMPVT |
| Post Translational Modifications | Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization. |
| Function | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. |
| Protein Name | Centrosomal Protein KizunaPolo-Like Kinase 1 Substrate 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCilium Basal BodyLocalizes To Centrosomes Throughout The Cell CycleAfter Centrosome DuplicationIt Usually Remains Associated Only With The Mother CentrosomeContaining The Older Mature Centriole And Particles Surrounding ItDuring ProphaseAdditional Particles Accumulate Around Both Separating CentrosomesDoes Not Accumulate At The Microtubule Minus EndsBut Instead Localizes To The Centrosomes And Centrosome-Surrounding Area In A Microtubule-Independent And Dependent MannerRespectively |
| Alternative Antibody Names | Anti-Centrosomal Protein Kizuna antibodyAnti-Polo-Like Kinase 1 Substrate 1 antibodyAnti-KIZ antibodyAnti-C20orf19 antibodyAnti-NCRNA00153 antibodyAnti-PLK1S1 antibodyAnti-HT013 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
