| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIRREL2 |
| Gene ID: | 84063 |
| Uniprot ID: | KIRR2_HUMAN |
| Immunogen Region: | 21-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human KIRREL2 (NP_954649.3). |
| Immunogen Sequence: | GPSPHFLQQPEDLVVLLGEE ARLPCALGAYWGLVQWTKSG LALGGQRDLPGWSRYWISGN AANGQHDLHIRPVELEDEAS YECQATQAGLRSRPAQLHVL VPPEAPQVLGGPSVSLVAGV PANLTCRSRGDARPTPELLW FRDGVLLDGATFHQTLLKEG TPGSVESTLTLTPFSHDDGA TFVCRARSQALPTGRDTAIT |
| Tissue Specificity | Highly expressed in beta-cells of the pancreatic islets. |
| Post Translational Modifications | N-glycosylated. The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase. |
| Function | May regulate basal insulin secretion. |
| Protein Name | Kin Of Irre-Like Protein 2Kin Of Irregular Chiasm-Like Protein 2Nephrin-Like Protein 3 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalized Along The Sites Of The Cell ContactsColocalizes With E-Cadherin And Beta-Catenin |
| Alternative Antibody Names | Anti-Kin Of Irre-Like Protein 2 antibodyAnti-Kin Of Irregular Chiasm-Like Protein 2 antibodyAnti-Nephrin-Like Protein 3 antibodyAnti-KIRREL2 antibodyAnti-NEPH3 antibodyAnti-UNQ5827 antibodyAnti-PRO19646 antibody |
Information sourced from Uniprot.org