| Tissue Specificity | Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). |
| Function | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. |
| Protein Name | Kinesin-Like Protein Kif16bSorting Nexin-23 |
| Database Links | Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonEarly Endosome MembraneSpindleIt Is Unclear Whether Association With Endosomes Is Mediated Via Phosphatidylinositol 3-Phosphate (Ptdins(3)P)-Binding Or Via Its Interaction With Rab14 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif16b antibodyAnti-Sorting Nexin-23 antibodyAnti-KIF16B antibodyAnti-C20orf23 antibodyAnti-KIAA1590 antibodyAnti-SNX23 antibody |
Information sourced from Uniprot.org
