| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
KDM2B |
| Gene ID: |
84678 |
| Uniprot ID: |
KDM2B_HUMAN |
| Immunogen Region: |
1059-1336 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1059-1336 of human KDM2B (NP_115979.3). |
| Immunogen Sequence: |
DGAAHVMHREVWMAVFSYLS HQDLCVCMRVCRTWNRWCCD KRLWTRIDLNHCKSITPLML SGIIRRQPVSLDLSWTNISK KQLSWLINRLPGLRDLVLSG CSWIAVSALCSSSCPLLRTL DVQWVEGLKDAQMRDLLSPP TDNRPGQMDNRSKLRNIVEL RLAGLDITDASLRLIIRHMP LLSKLHLSYCNHVTDQSINL LTAVGTTTRDSLTEINLSDC NKVTDQCLSFFKRCGNICH |
| Function | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). |
| Protein Name | Lysine-Specific Demethylase 2bCxxc-Type Zinc Finger Protein 2F-Box And Leucine-Rich Repeat Protein 10F-Box Protein Fbl10F-Box/Lrr-Repeat Protein 10Jmjc Domain-Containing Histone Demethylation Protein 1bJumonji Domain-Containing Emsy-Interactor Methyltransferase Motif ProteinProtein JemmaProtein-Containing Cxxc Domain 2Histone-H3-Lysine-36 Demethylase 1b |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | NucleusNucleolusChromosome |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 2b antibodyAnti-Cxxc-Type Zinc Finger Protein 2 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 10 antibodyAnti-F-Box Protein Fbl10 antibodyAnti-F-Box/Lrr-Repeat Protein 10 antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1b antibodyAnti-Jumonji Domain-Containing Emsy-Interactor Methyltransferase Motif Protein antibodyAnti-Protein Jemma antibodyAnti-Protein-Containing Cxxc Domain 2 antibodyAnti-Histone-H3-Lysine-36 Demethylase 1b antibodyAnti-KDM2B antibodyAnti-CXXC2 antibodyAnti-FBL10 antibodyAnti-FBXL10 antibodyAnti-JHDM1B antibodyAnti-NDY1 antibodyAnti-PCCX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
