| Tissue Specificity | Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. |
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. Isoform A-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2Eag HomologEther-A-Go-Go-Related Gene Potassium Channel 1Erg-1Eag-Related Protein 1Ether-A-Go-Go-Related Protein 1H-ErgHerg-1Herg1Potassium Voltage-Gated Channel Subfamily H Member 2Voltage-Gated Potassium Channel Subunit Kv11.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh2 antibodyAnti-Eag Homolog antibodyAnti-Ether-A-Go-Go-Related Gene Potassium Channel 1 antibodyAnti-Erg-1 antibodyAnti-Eag-Related Protein 1 antibodyAnti-Ether-A-Go-Go-Related Protein 1 antibodyAnti-H-Erg antibodyAnti-Herg-1 antibodyAnti-Herg1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv11.1 antibodyAnti-KCNH2 antibodyAnti-ERG antibodyAnti-ERG1 antibodyAnti-HERG antibody |
Information sourced from Uniprot.org
