| Post Translational Modifications | N-glycosylation promotes the cell surface expression. Phosphorylation on Tyr-499 inhibits its channel activity. |
| Function | Isoform 1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Isoform 2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Isoform 3: Lacks voltage-gated potassium channel activity. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily A Member 3Hgk5Hlk3Hpcn3Voltage-Gated K(+ Channel HukiiiVoltage-Gated Potassium Channel Subunit Kv1.3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Cell MembraneIsoform 3: CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily A Member 3 antibodyAnti-Hgk5 antibodyAnti-Hlk3 antibodyAnti-Hpcn3 antibodyAnti-Voltage-Gated K(+ Channel Hukiii antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv1.3 antibodyAnti-KCNA3 antibodyAnti-HGK5 antibody |
Information sourced from Uniprot.org
