| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JAKMIP1 |
| Gene ID: | 152789 |
| Uniprot ID: | JKIP1_HUMAN |
| Immunogen Region: | 337-626 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 337-626 of human JAKMIP1 (NP_653321.1). |
| Immunogen Sequence: | KRMNKKNEDLLQSIQRMEEK IKNLTRENVEMKEKLSAQAS LKRHTSLNDLSLTRDEQEIE FLRLQVLEQQHVIDDLSLER ERLLRSKRHRGKSLKPPKKH VVETFFGFDEESVDSETLSE TSYNTDRTDRTPATPEEDLD DATAREEADLRFCQLTREYQ ALQRAYALLQEQVGGTLDAE REARTREQLQADLLRCQAKI EDLEKLLVEKGQDSKWVEEK QLLIRTNQDLLEKIYRLEM |
| Tissue Specificity | Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine. |
| Function | Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. |
| Protein Name | Janus Kinase And Microtubule-Interacting Protein 1 Gaba-B Receptor-Binding Protein Multiple Alpha-Helices And Rna-Linker Protein 1 Marlin-1 |
| Cellular Localisation | Cytoplasm Cytoskeleton Membrane Peripheral Membrane Protein Colocalizes With The Microtubule Network Localizes To The Cell Body And Neurites Of Hippocampal Neurons Where It Accumulates In Granules Localizes To The Tail And To A Lower Extent To The Head Of Sperm Cells |
| Alternative Antibody Names | Anti-Janus Kinase And Microtubule-Interacting Protein 1 antibody Anti-Gaba-B Receptor-Binding Protein antibody Anti-Multiple Alpha-Helices And Rna-Linker Protein 1 antibody Anti-Marlin-1 antibody Anti-JAKMIP1 antibody Anti-GABABRBP antibody Anti-JAMIP1 antibody Anti-MARLIN1 antibody |
Information sourced from Uniprot.org