Western blot analysis of extracts of various cell lines, using (STJ11105750) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.

Anti-ITPA antibody (70-150) [S5750RM] (STJ11105750)

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STJ11105750
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S5750RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITPA
Gene ID: 3704
Uniprot ID: ITPA_HUMAN
Immunogen Region: 70-150
Specificity: A synthetic peptide corresponding to a sequence within amino acids 70-150 of human ITPA (Q9BY32).
Immunogen Sequence: VEDTCLCFNALGGLPGPYIK WFLEKLKPEGLHQLLAGFED KSAYALCTFALSTGDPSQPV RLFRGRTSGRIVAPRGCQDF G
Tissue Specificity Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Protein Name Inosine Triphosphate Pyrophosphatase
Itpase
Inosine Triphosphatase
Non-Canonical Purine Ntp Pyrophosphatase
Non-Standard Purine Ntp Pyrophosphatase
Nucleoside-Triphosphate Diphosphatase
Nucleoside-Triphosphate Pyrophosphatase
Ntpase
Putative Oncogene Protein Hlc14-06-P
Database Links Reactome: R-HSA-74259
Reactome: R-HSA-9755088
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Inosine Triphosphate Pyrophosphatase antibody
Anti-Itpase antibody
Anti-Inosine Triphosphatase antibody
Anti-Non-Canonical Purine Ntp Pyrophosphatase antibody
Anti-Non-Standard Purine Ntp Pyrophosphatase antibody
Anti-Nucleoside-Triphosphate Diphosphatase antibody
Anti-Nucleoside-Triphosphate Pyrophosphatase antibody
Anti-Ntpase antibody
Anti-Putative Oncogene Protein Hlc14-06-P antibody
Anti-ITPA antibody
Anti-C20orf37 antibody
Anti-My049 antibody
Anti-OK antibody
Anti-SW-cl.9 antibody

Information sourced from Uniprot.org

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