| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ITLN1 (19-313) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITLN1 |
| Gene ID: |
55600 |
| Uniprot ID: |
ITLN1_HUMAN |
| Immunogen Region: |
19-313 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 19-313 of human ITLN1 (NP_060095.2). |
| Immunogen Sequence: |
TDEANTYFKEWTCSSSPSLP RSCKEIKDECPSAFDGLYFL RTENGVIYQTFCDMTSGGGG WTLVASVHENDMRGKCTVGD RWSSQQGSKAVYPEGDGNWA NYNTFGSAEAATSDDYKNPG YYDIQAKDLGIWHVPNKSPM QHWRNSSLLRYRTDTGFLQT LGHNLFGIYQKYPVKYGEGK CWTDNGPVIPVVYDFGDAQK TASYYSPYGQREFTAGFVQF RVFNNERAANALCAGMRVT |
| Tissue Specificity | Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. |
| Post Translational Modifications | N-glycosylated. |
| Function | Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption. |
| Protein Name | Intelectin-1Itln-1Endothelial Lectin Hl-1Galactofuranose-Binding LectinIntestinal Lactoferrin ReceptorOmentin |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedEnriched In Lipid Rafts |
| Alternative Antibody Names | Anti-Intelectin-1 antibodyAnti-Itln-1 antibodyAnti-Endothelial Lectin Hl-1 antibodyAnti-Galactofuranose-Binding Lectin antibodyAnti-Intestinal Lactoferrin Receptor antibodyAnti-Omentin antibodyAnti-ITLN1 antibodyAnti-INTL antibodyAnti-ITLN antibodyAnti-LFR antibodyAnti-UNQ640 antibodyAnti-PRO1270 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
