| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGAM |
| Gene ID: | 3684 |
| Uniprot ID: | ITAM_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD11b (NP_000623.2). |
| Immunogen Sequence: | MALRVLLLTALTLCHGFNLD TENAMTFQENARGFGQSVVQ LQGSRVVVGAPQEIVAANQR GSLYQCDYSTGSCEPIRLQV PVEAVNMSLGLSLAATTSPP |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. Expressed in neutrophils (at protein level). |
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-M Cd11 Antigen-Like Family Member B Cr-3 Alpha Chain Cell Surface Glycoprotein Mac-1 Subunit Alpha Leukocyte Adhesion Receptor Mo1 Neutrophil Adherence Receptor Cd Antigen Cd11b |
| Database Links | Reactome: R-HSA-166016 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft |
| Alternative Antibody Names | Anti-Integrin Alpha-M antibody Anti-Cd11 Antigen-Like Family Member B antibody Anti-Cr-3 Alpha Chain antibody Anti-Cell Surface Glycoprotein Mac-1 Subunit Alpha antibody Anti-Leukocyte Adhesion Receptor Mo1 antibody Anti-Neutrophil Adherence Receptor antibody Anti-Cd Antigen Cd11b antibody Anti-ITGAM antibody Anti-CD11B antibody Anti-CR3A antibody |
Information sourced from Uniprot.org