| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | IRX3 |
| Gene ID: | 79191 |
| Uniprot ID: | IRX3_HUMAN |
| Immunogen Region: | 50-150 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IRX3 (NP_077312.2). |
| Immunogen Sequence: | SNVLSSVYGAPYAAAAAAAA AQGYGAFLPYAAELPIFPQL GAQYELKDSPGVQHPAAAAA FPHPHPAFYPYGQYQFGDPS RPKNATRESTSTLKAWLNEH R |
| Function | Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. |
| Protein Name | Iroquois-Class Homeodomain Protein Irx-3Homeodomain Protein Irxb1Iroquois Homeobox Protein 3 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Iroquois-Class Homeodomain Protein Irx-3 antibodyAnti-Homeodomain Protein Irxb1 antibodyAnti-Iroquois Homeobox Protein 3 antibodyAnti-IRX3 antibodyAnti-IRXB1 antibody |
Information sourced from Uniprot.org