| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IQSEC1 (180-380) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IQSEC1 |
| Gene ID: |
9922 |
| Uniprot ID: |
IQEC1_HUMAN |
| Immunogen Region: |
180-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3). |
| Immunogen Sequence: |
SFEGPEKVHSSYFEGKQVSV TNDGSQLGALVSPECGDLSE PTTLKSPAPSSDFADAITEL EDAFSRQVKSLAESIDDALN CRSLHTEEAPALDAARARDT EPQTALHGMDHRKLDEMTAS YSDVTLYIDEEELSPPLPLS QAGDRPSSTESDLRLRAGGA APDYWALAHKEDKADTDTSC RSTPSLERQEQRLRVEHLPL L |
| Tissue Specificity | Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. |
| Function | Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors. |
| Protein Name | Iq Motif And Sec7 Domain-Containing Protein 1Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 100Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 2Brefeldin-Resistant Arf-Gef 2 ProteinBrag2 |
| Cellular Localisation | CytoplasmNucleusPostsynaptic DensityCytoplasmic VesicleSecretory VesicleSynaptic VesicleAt Steady StateMay Be Preferentially Cytosolic |
| Alternative Antibody Names | Anti-Iq Motif And Sec7 Domain-Containing Protein 1 antibodyAnti-Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 100 antibodyAnti-Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 2 antibodyAnti-Brefeldin-Resistant Arf-Gef 2 Protein antibodyAnti-Brag2 antibodyAnti-IQSEC1 antibodyAnti-ARFGEP100 antibodyAnti-BRAG2 antibodyAnti-KIAA0763 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
