| Tissue Specificity | Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. |
| Function | Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors. |
| Protein Name | Iq Motif And Sec7 Domain-Containing Protein 1Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 100Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 2Brefeldin-Resistant Arf-Gef 2 ProteinBrag2 |
| Cellular Localisation | CytoplasmNucleusPostsynaptic DensityCytoplasmic VesicleSecretory VesicleSynaptic VesicleAt Steady StateMay Be Preferentially Cytosolic |
| Alternative Antibody Names | Anti-Iq Motif And Sec7 Domain-Containing Protein 1 antibodyAnti-Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 100 antibodyAnti-Adp-Ribosylation Factors Guanine Nucleotide-Exchange Protein 2 antibodyAnti-Brefeldin-Resistant Arf-Gef 2 Protein antibodyAnti-Brag2 antibodyAnti-IQSEC1 antibodyAnti-ARFGEP100 antibodyAnti-BRAG2 antibodyAnti-KIAA0763 antibody |
Information sourced from Uniprot.org
