| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INTS5 |
| Gene ID: | 80789 |
| Uniprot ID: | INT5_HUMAN |
| Immunogen Region: | 120-400 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human INTS5 (NP_085131.1). |
| Immunogen Sequence: | DVVQEVQQVLSEFIRANPKA WAPVISAWSIDLMGQLSSTY SGQHQRVPHATGALNELLQL WMGCRATRTLMDIYVQCLSA LIGSCPDACVDALLDTSVQH SPHFDWVVAHIGSSFPGTII SRVLSCGLKDFCVHGGAGGG AGSSGGSSSQTPSTDPFPGS PAIPAEKRVPKIASVVGILG HLASRHGDSIRRELLRMFHD SLAGGSGGRSGDPSLQATVP FLLQLAVMSPALLGTVSGE |
| Function | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. |
| Protein Name | Integrator Complex Subunit 5 Int5 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus Membrane Multi-Pass Membrane Protein Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 5 antibody Anti-Int5 antibody Anti-INTS5 antibody Anti-KIAA1698 antibody |
Information sourced from Uniprot.org