• Western blot analysis of extracts of various cell lines, using ING2 antibody (STJ114156) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-ING2 antibody (20-180) (STJ114156)

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STJ114156

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ING2 (20-180) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ING2
Gene ID: 3622
Uniprot ID: ING2_HUMAN
Immunogen Region: 20-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human ING2 (NP_001555.1).
Immunogen Sequence: RSRLLTCYVQDYLECVESLP HDMQRNVSVLRELDNKYQET LKEIDDVYEKYKKEDDLNQK KRLQQLLQRALINSQELGDE KIQIVTQMLELVENRARQME LHSQCFQDPAESERASDKAK MDSSQPERSSRRPRRQRTSE SRDLCHMANGIEDCDDQPPK E
Tissue Specificity Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Post Translational Modifications Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Function Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Protein Name Inhibitor Of Growth Protein 2
Inhibitor Of Growth 1-Like Protein
Ing1lp
P32
P33ing2
Database Links Reactome: R-HSA-3899300
Reactome: R-HSA-6811555
Cellular Localisation Nucleus
Predominantly Nuclear
Localized To Chromatin And Nuclear Matrix
Upon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin And
At Least Partially
Translocated To The Cytoplasm
Alternative Antibody Names Anti-Inhibitor Of Growth Protein 2 antibody
Anti-Inhibitor Of Growth 1-Like Protein antibody
Anti-Ing1lp antibody
Anti-P32 antibody
Anti-P33ing2 antibody
Anti-ING2 antibody
Anti-ING1L antibody

Information sourced from Uniprot.org

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