| Tissue Specificity | Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. |
| Function | Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. |
| Protein Name | Interleukin-27 Receptor Subunit AlphaIl-27 Receptor Subunit AlphaIl-27r Subunit AlphaIl-27r-AlphaIl-27raCytokine Receptor Wsx-1Cytokine Receptor-Like 1Type I T-Cell Cytokine ReceptorTccrZcytor1 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-27 Receptor Subunit Alpha antibodyAnti-Il-27 Receptor Subunit Alpha antibodyAnti-Il-27r Subunit Alpha antibodyAnti-Il-27r-Alpha antibodyAnti-Il-27ra antibodyAnti-Cytokine Receptor Wsx-1 antibodyAnti-Cytokine Receptor-Like 1 antibodyAnti-Type I T-Cell Cytokine Receptor antibodyAnti-Tccr antibodyAnti-Zcytor1 antibodyAnti-IL27RA antibodyAnti-CRL1 antibodyAnti-TCCR antibodyAnti-WSX1 antibodyAnti-UNQ296 antibodyAnti-PRO336 antibody |
Information sourced from Uniprot.org
