| Tissue Specificity | Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil. |
| Function | Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. |
| Protein Name | Interleukin-1 Family Member 10Il-1f10Family Of Interleukin 1-ThetaFil1 ThetaInterleukin-1 Hy2Il-1hy2Interleukin-1 ThetaIl-1 ThetaInterleukin-38Il-38 |
| Database Links | Reactome: R-HSA-9007892Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-1 Family Member 10 antibodyAnti-Il-1f10 antibodyAnti-Family Of Interleukin 1-Theta antibodyAnti-Fil1 Theta antibodyAnti-Interleukin-1 Hy2 antibodyAnti-Il-1hy2 antibodyAnti-Interleukin-1 Theta antibodyAnti-Il-1 Theta antibodyAnti-Interleukin-38 antibodyAnti-Il-38 antibodyAnti-IL1F10 antibodyAnti-FIL1T antibodyAnti-IL1HY2 antibodyAnti-IL38 antibodyAnti-FKSG75 antibodyAnti-UNQ6119 antibodyAnti-PRO20041 antibody |
Information sourced from Uniprot.org
