| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-3Ifn-Lambda-3Cytokine Zcyto22Interleukin-28bIl-28bInterleukin-28cIl-28c |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-3 antibodyAnti-Ifn-Lambda-3 antibodyAnti-Cytokine Zcyto22 antibodyAnti-Interleukin-28b antibodyAnti-Il-28b antibodyAnti-Interleukin-28c antibodyAnti-Il-28c antibodyAnti-IFNL3 antibodyAnti-IL28B antibodyAnti-IL28C antibodyAnti-ZCYTO22 antibody |
Information sourced from Uniprot.org
