• Immunohistochemistry analysis of paraffin-embedded mouse lung using IFNL3 antibody (STJ114774) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human gastric cancer using IFNL3 antibody (STJ114774) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human stomach using IFNL3 antibody (STJ114774) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded rat brain using IFNL3 antibody (STJ114774) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-IFNL3 antibody (22-196) (STJ114774)

SKU:
STJ114774

£112.50 - £524.50
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Host: Rabbit
Applications: IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IFNL3
Gene ID: 282617
Uniprot ID: IFNL3_HUMAN
Immunogen Region: 22-196
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2).
Immunogen Sequence: VPVARLRGALPDARGCHIAQ FKSLSPQELQAFKRAKDALE ESLLLKDCKCRSRLFPRTWD LRQLQVRERPVALEAELALT LKVLEATADTDPALGDVLDQ PLHTLHHILSQLRACIQPQP TAGPRTRGRLHHWLHRLQEA PKKESPGCLEASVTFNLFRL LTRDLNCVASGDLCV
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Name Interferon Lambda-3
Ifn-Lambda-3
Cytokine Zcyto22
Interleukin-28b
Il-28b
Interleukin-28c
Il-28c
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interferon Lambda-3 antibody
Anti-Ifn-Lambda-3 antibody
Anti-Cytokine Zcyto22 antibody
Anti-Interleukin-28b antibody
Anti-Il-28b antibody
Anti-Interleukin-28c antibody
Anti-Il-28c antibody
Anti-IFNL3 antibody
Anti-IL28B antibody
Anti-IL28C antibody
Anti-ZCYTO22 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance