| Function | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 2Ifit-2Isg-54 KInterferon-Induced 54 Kda ProteinIfi-54kP54 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 2 antibodyAnti-Ifit-2 antibodyAnti-Isg-54 K antibodyAnti-Interferon-Induced 54 Kda Protein antibodyAnti-Ifi-54k antibodyAnti-P54 antibodyAnti-IFIT2 antibodyAnti-CIG-42 antibodyAnti-G10P2 antibodyAnti-IFI54 antibodyAnti-ISG54 antibody |
Information sourced from Uniprot.org
