| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HVCN1 (10-100 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Hvcn1 |
| Gene ID: |
74096 |
| Uniprot ID: |
HVCN1_MOUSE |
| Immunogen Region: |
10-100 aa |
| Specificity: |
Specific for HVCN1. |
| Immunogen: |
A synthetic peptide from aa region 10-100 of mouse HVCN1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated in vitro by PRKCD. Phosphorylation may enhance channel gating. |
| Function | Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain. Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst. Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa. |
| Protein Name | Voltage-Gated Hydrogen Channel 1Hydrogen Voltage-Gated Channel 1Hv1Voltage Sensor Domain-Only ProteinMvsop |
| Database Links | Reactome: R-MMU-1222556Reactome: -MMU-1300642Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmic VesiclePhagosome MembraneCell ProjectionCiliumFlagellum MembraneDetected Within The Principal Piece Of The Sperm Flagellum |
| Alternative Antibody Names | Anti-Voltage-Gated Hydrogen Channel 1 antibodyAnti-Hydrogen Voltage-Gated Channel 1 antibodyAnti-Hv1 antibodyAnti-Voltage Sensor Domain-Only Protein antibodyAnti-Mvsop antibodyAnti-Hvcn1 antibodyAnti-Bts antibodyAnti-Vsop antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
