| Post Translational Modifications | Phosphorylated in vitro by PRKCD. Phosphorylation may enhance channel gating. |
| Function | Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain. Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst. Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa. |
| Protein Name | Voltage-Gated Hydrogen Channel 1Hydrogen Voltage-Gated Channel 1Hv1Voltage Sensor Domain-Only ProteinMvsop |
| Database Links | Reactome: R-MMU-1222556Reactome: -MMU-1300642Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmic VesiclePhagosome MembraneCell ProjectionCiliumFlagellum MembraneDetected Within The Principal Piece Of The Sperm Flagellum |
| Alternative Antibody Names | Anti-Voltage-Gated Hydrogen Channel 1 antibodyAnti-Hydrogen Voltage-Gated Channel 1 antibodyAnti-Hv1 antibodyAnti-Voltage Sensor Domain-Only Protein antibodyAnti-Mvsop antibodyAnti-Hvcn1 antibodyAnti-Bts antibodyAnti-Vsop antibody |
Information sourced from Uniprot.org
