| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S1MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSPA2 |
| Gene ID: | 3306 |
| Uniprot ID: | HSP72_HUMAN |
| Immunogen Region: | 488-637 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 488-637 of human HSPA2 (P54652). |
| Immunogen Sequence: | ILNVTAADKSTGKENKITIT NDKGRLSKDDIDRMVQEAER YKSEDEANRDRVAAKNALES YTYNIKQTVEDEKLRGKISE QDKNKILDKCQEVINWLDRN QMAEKDEYEHKQKELERVCN PIISKLYQGGPGGGSGGGGS GASGGPTIEE |
| Function | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells. |
| Protein Name | Heat Shock-Related 70 Kda Protein 2 Heat Shock 70 Kda Protein 2 Heat Shock Protein Family A Member 2 |
| Database Links | Reactome: R-HSA-1221632 Reactome: R-HSA-3371453 Reactome: R-HSA-3371497 Reactome: R-HSA-3371568 Reactome: R-HSA-9833482 |
| Cellular Localisation | Cytoplasm Cytoskeleton Spindle Colocalizes With Shcbp1l At Spindle During The Meiosis Process |
| Alternative Antibody Names | Anti-Heat Shock-Related 70 Kda Protein 2 antibody Anti-Heat Shock 70 Kda Protein 2 antibody Anti-Heat Shock Protein Family A Member 2 antibody Anti-HSPA2 antibody |
Information sourced from Uniprot.org