| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-15-hydroxyprostaglandin dehydrogenase (192-242 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HPGD |
| Gene ID: |
3248 |
| Uniprot ID: |
PGDH_HUMAN |
| Immunogen Region: |
192-242 aa |
| Specificity: |
This antibody detects endogenous levels of PGDH at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human PGDH at the amino acid range 192-242 |
| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation. |
| Protein Name | 15-Hydroxyprostaglandin Dehydrogenase Nad(+15-PgdhEicosanoid/Docosanoid Dehydrogenase Nad(+Prostaglandin Dehydrogenase 1Short Chain Dehydrogenase/Reductase Family 36c Member 1 |
| Database Links | Reactome: R-HSA-2142700Reactome: R-HSA-2162123Reactome: R-HSA-9018676Reactome: R-HSA-9018896 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-15-Hydroxyprostaglandin Dehydrogenase Nad(+ antibodyAnti-15-Pgdh antibodyAnti-Eicosanoid/Docosanoid Dehydrogenase Nad(+ antibodyAnti-Prostaglandin Dehydrogenase 1 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 36c Member 1 antibodyAnti-HPGD antibodyAnti-PGDH1 antibodyAnti-SDR36C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
