| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HORMA domain-containing protein 1 (321-370 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HORMAD1 |
| Gene ID: |
84072 |
| Uniprot ID: |
HORM1_HUMAN |
| Immunogen Region: |
321-370 aa |
| Specificity: |
HORMAD1 Polyclonal Antibody detects endogenous levels of HORMAD1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human HORMAD1 at the amino acid range 321-370 |
| Post Translational Modifications | Phosphorylated at Ser-377 in a SPO11-dependent manner. |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. |
| Protein Name | Horma Domain-Containing Protein 1Cancer/Testis Antigen 46Ct46Newborn Ovary Horma Protein |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed ChromosomesThe Expression Of The Phosphorylated Form At Ser-377 Is Restricted To Unsynapsed Chromosomal Regions |
| Alternative Antibody Names | Anti-Horma Domain-Containing Protein 1 antibodyAnti-Cancer/Testis Antigen 46 antibodyAnti-Ct46 antibodyAnti-Newborn Ovary Horma Protein antibodyAnti-HORMAD1 antibodyAnti-NOHMA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
