Anti-HORMAD1 antibody (321-370 aa) (STJ93572)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human HORMAD1 at the amino acid range 321-370
General Information
| Short Description | Rabbit polyclonal anti-HORMA domain-containing protein 1 (321-370 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HORMAD1 |
| Gene ID | 84072 |
| Uniprot ID | HORM1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human HORMAD1 at the amino acid range 321-370 |
| Immunogen Region | 321-370 aa |
| Specificity | HORMAD1 Polyclonal Antibody detects endogenous levels of HORMAD1 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-377 in a SPO11-dependent manner. |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. |
| Protein Name | Horma Domain-Containing Protein 1Cancer/Testis Antigen 46Ct46Newborn Ovary Horma Protein |
| Database Links | |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed ChromosomesThe Expression Of The Phosphorylated Form At Ser-377 Is Restricted To Unsynapsed Chromosomal Regions |
| Alternative Antibody Names | Anti-Horma Domain-Containing Protein 1 antibodyAnti-Cancer/Testis Antigen 46 antibodyAnti-Ct46 antibodyAnti-Newborn Ovary Horma Protein antibodyAnti-HORMAD1 antibodyAnti-NOHMA antibody |
Information sourced from Uniprot.org