| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HNRNPDL |
| Gene ID: | 9987 |
| Uniprot ID: | HNRDL_HUMAN |
| Immunogen Region: | 261-420 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-420 of human HNRNPDL (NP_112740.1). |
| Immunogen Sequence: | NIELPMDTKTNERRGFCFIT YTDEEPVKKLLESRYHQIGS GKCEIKVAQPKEVYRQQQQQ QKGGRGAAAGGRGGTRGRGR GQGQNWNQGFNNYYDQGYGN YNSAYGGDQNYSGYGGYDYT GYNYGNYGYGQGYADYSGQQ STYGKASRGGGNHQNNYQPY |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. |
| Post Translational Modifications | Dimethylation of Arg-408 is probably of the asymmetric type. |
| Function | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. |
| Protein Name | Heterogeneous Nuclear Ribonucleoprotein D-Like Hnrnp D-Like Hnrnp Dl Au-Rich Element Rna-Binding Factor Jkt41-Binding Protein Protein Laauf1 |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | Nucleus Cytoplasm Shuttles Between The Nucleus And The Cytoplasm In A Tnpo1-Dependent Manner |
| Alternative Antibody Names | Anti-Heterogeneous Nuclear Ribonucleoprotein D-Like antibody Anti-Hnrnp D-Like antibody Anti-Hnrnp Dl antibody Anti-Au-Rich Element Rna-Binding Factor antibody Anti-Jkt41-Binding Protein antibody Anti-Protein Laauf1 antibody Anti-HNRNPDL antibody Anti-HNRPDL antibody Anti-JKTBP antibody |
Information sourced from Uniprot.org