| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HLA-DOB |
| Gene ID: | 3112 |
| Uniprot ID: | DOB_HUMAN |
| Immunogen Region: | 27-224 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-224 of human HLA-DOB (NP_002111.1). |
| Immunogen Sequence: | TDSPEDFVIQAKADCYFTNG TEKVQFVVRFIFNLEEYVRF DSDVGMFVALTKLGQPDAEQ WNSRLDLLERSRQAVDGVCR HNYRLGAPFTVGRKVQPEVT VYPERTPLLHQHNLLHCSVT GFYPGDIKIKWFLNGQEERA GVMSTGPIRNGDWTFQTVVM LEMTPELGHVYTCLVDHSSL LSPVSVEWRAQSEYSWRK |
| Function | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Do Beta ChainMhc Class Ii Antigen Dob |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneComplexes With Hla-Dm Molecule During Intracellular Transport And In Endosomal/Lysosomal CompartmentsHeterotetramerization Is Necessary To Exit The Er |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Do Beta Chain antibodyAnti-Mhc Class Ii Antigen Dob antibodyAnti-HLA-DOB antibody |
Information sourced from Uniprot.org