| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HLA-DOB (27-224) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HLA-DOB |
| Gene ID: |
3112 |
| Uniprot ID: |
DOB_HUMAN |
| Immunogen Region: |
27-224 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-224 of human HLA-DOB (NP_002111.1). |
| Immunogen Sequence: |
TDSPEDFVIQAKADCYFTNG TEKVQFVVRFIFNLEEYVRF DSDVGMFVALTKLGQPDAEQ WNSRLDLLERSRQAVDGVCR HNYRLGAPFTVGRKVQPEVT VYPERTPLLHQHNLLHCSVT GFYPGDIKIKWFLNGQEERA GVMSTGPIRNGDWTFQTVVM LEMTPELGHVYTCLVDHSSL LSPVSVEWRAQSEYSWRK |
| Function | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Do Beta ChainMhc Class Ii Antigen Dob |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneComplexes With Hla-Dm Molecule During Intracellular Transport And In Endosomal/Lysosomal CompartmentsHeterotetramerization Is Necessary To Exit The Er |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Do Beta Chain antibodyAnti-Mhc Class Ii Antigen Dob antibodyAnti-HLA-DOB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
