| Background | Human herpesvirus type 8 (HHV-8) is the likely etiological agent of Kaposi s sarcoma (KS). HHV-8 DNA sequences have been found in Kaposi s sarcoma lesions, primary effusion lymphoma, and multicentric Castleman s disease via polymerase chain reaction and in situ hybridization. Latent nuclear antigen (LNA1, LNA, LANA-1) , also known as ORF73, is a 222-or 234 kD protein that is consistently expressed in HHV8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry |
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