| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | HESX1 |
| Gene ID: | 8820 |
| Uniprot ID: | HESX1_HUMAN |
| Immunogen Region: | 1-185 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human HESX1 (NP_003856.1). |
| Immunogen Sequence: | MSPSLQEGAQLGENKPSTCS FSIERILGLDQKKDCVPLMK PHRPWADTCSSSGKDGNLCL HVPNPPSGISFPSVVDHPMP EERASKYENYFSASERLSLK RELSWYRGRRPRTAFTQNQI EVLENVFRVNCYPGIDIRED LAQKLNLEEDRIQIWFQNRR AKLKRSHRESQFLMAKKNFN TNLLE |
| Function | Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. |
| Protein Name | Homeobox Expressed In Es Cells 1Homeobox Protein AnfHanf |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Expressed In Es Cells 1 antibodyAnti-Homeobox Protein Anf antibodyAnti-Hanf antibodyAnti-HESX1 antibodyAnti-HANF antibody |
Information sourced from Uniprot.org
