| Function | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Modulates also iron metabolism by regulating the basal turnover of FBXL5. |
| Protein Name | E3 Ubiquitin-Protein Ligase Herc2Hect Domain And Rcc1-Like Domain-Containing Protein 2Hect-Type E3 Ubiquitin Transferase Herc2 |
| Database Links | Reactome: R-HSA-3108214Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleNucleusRecruited To Sites Of Dna Damage In Response To Ionizing Radiation (Ir) Via Its Interaction With Rnf8May Loose Association With Centrosomes During Mitosis |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Herc2 antibodyAnti-Hect Domain And Rcc1-Like Domain-Containing Protein 2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Herc2 antibodyAnti-HERC2 antibody |
Information sourced from Uniprot.org
