| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HDAC10 (400-669) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HDAC10 |
| Gene ID: |
83933 |
| Uniprot ID: |
HDA10_HUMAN |
| Immunogen Region: |
400-669 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-669 of human HDAC10 (NP_114408.3). |
| Immunogen Sequence: |
DQPCLCPAPSVRTAVALTTP DITLVLPPDVIQQEASALRE ETEAWARPHESLAREEALTA LGKLLYLLDGMLDGQVNSGI AATPASAAAATLDVAVRRGL SHGAQRLLCVALGQLDRPPD LAHDGRSLWLNIRGKEAAAL SMFHVSTPLPVMTGGFLSCI LGLVLPLAYGFQPDLVLVAL GPGHGLQGPHAALLAAMLRG LAGGRVLALLEENSTPQLAG ILARVLNGEAPPSLGPSSV |
| Tissue Specificity | Widely expressed with high levels in liver and kidney. |
| Function | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair. |
| Protein Name | Polyamine Deacetylase Hdac10Histone Deacetylase 10Hd10 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054 |
| Cellular Localisation | CytoplasmNucleusExcluded From Nucleoli |
| Alternative Antibody Names | Anti-Polyamine Deacetylase Hdac10 antibodyAnti-Histone Deacetylase 10 antibodyAnti-Hd10 antibodyAnti-HDAC10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
