Anti-HCN2 antibody (800-889) (STJ11100295)

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STJ11100295
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HCN2
Gene ID: 610
Uniprot ID: HCN2_HUMAN
Immunogen Region: 800-889
Specificity: A synthetic peptide corresponding to a sequence within amino acids 800-889 of human HCN2 (NP_001185.3).
Immunogen Sequence: AAPLAGPALPARRLSRASRP LSASQPSLPHGAPGPAASTR PASSSTPRLGPTPAARAAAP SPDRRDSASPGAAGGLDPQD SARSRLSSNL
Tissue Specificity Highly expressed throughout the brain. Detected at low levels in heart.
Post Translational Modifications Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2.
Function Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons.
Protein Name Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
Brain Cyclic Nucleotide-Gated Channel 2
Bcng-2
Database Links Reactome: R-HSA-1296061
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Brain Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Bcng-2 antibody
Anti-HCN2 antibody
Anti-BCNG2 antibody

Information sourced from Uniprot.org

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