| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HCN2 (800-889) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HCN2 |
| Gene ID: |
610 |
| Uniprot ID: |
HCN2_HUMAN |
| Immunogen Region: |
800-889 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 800-889 of human HCN2 (NP_001185.3). |
| Immunogen Sequence: |
AAPLAGPALPARRLSRASRP LSASQPSLPHGAPGPAASTR PASSSTPRLGPTPAARAAAP SPDRRDSASPGAAGGLDPQD SARSRLSSNL |
| Tissue Specificity | Highly expressed throughout the brain. Detected at low levels in heart. |
| Post Translational Modifications | Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. |
| Function | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH.acidic pH shifts the activation to more negative voltages. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2Brain Cyclic Nucleotide-Gated Channel 2Bcng-2 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Bcng-2 antibodyAnti-HCN2 antibodyAnti-BCNG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
