| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HCN2 |
| Gene ID: |
610 |
| Uniprot ID: |
HCN2_HUMAN |
| Immunogen Region: |
800-889 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 800-889 of human HCN2 (NP_001185.3). |
| Immunogen Sequence: |
AAPLAGPALPARRLSRASRP LSASQPSLPHGAPGPAASTR PASSSTPRLGPTPAARAAAP SPDRRDSASPGAAGGLDPQD SARSRLSSNL |
| Tissue Specificity | Highly expressed throughout the brain. Detected at low levels in heart. |
| Post Translational Modifications | Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2. |
| Function | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2Brain Cyclic Nucleotide-Gated Channel 2Bcng-2 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Bcng-2 antibodyAnti-HCN2 antibodyAnti-BCNG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
