| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HBP1 |
| Gene ID: | 26959 |
| Uniprot ID: | HBP1_HUMAN |
| Immunogen Region: | 215-514 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2). |
| Immunogen Sequence: | FLKGTRLCFHKGSNKEWQDV EDFARAEGCDNEEDLQMGIH KGYGSDGLKLLSHEESVSFG ESVLKLTFDPGTVEDGLLTV ECKLDHPFYVKNKGWSSFYP SLTVVQHGIPCCEVHIGDVC LPPGHPDAINFDDSGVFDTF KSYDFTPMDSSAVYVLSSMA RQRRASLSCGGPGGQDFARS GFSKNCGSPGSSQLSSNSLY AKAVKNHSSGTVSATSPNKC KRPMNAFMLFAKKYRVEYT |
| Post Translational Modifications | Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. |
| Function | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. |
| Protein Name | Hmg Box-Containing Protein 1Hmg Box Transcription Factor 1High Mobility Group Box Transcription Factor 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hmg Box-Containing Protein 1 antibodyAnti-Hmg Box Transcription Factor 1 antibodyAnti-High Mobility Group Box Transcription Factor 1 antibodyAnti-HBP1 antibody |
Information sourced from Uniprot.org