| Tissue Specificity | Specifically expressed in liver (at protein level). |
| Post Translational Modifications | Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. Phosphorylation at Ser-8 is not required for interaction with GYG1. Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641. |
| Function | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name | Glycogen Starch Synthase - LiverGlycogen Synthase 2 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3858516Reactome: R-HSA-3878781 |
| Alternative Antibody Names | Anti-Glycogen Starch Synthase - Liver antibodyAnti-Glycogen Synthase 2 antibodyAnti-GYS2 antibody |
Information sourced from Uniprot.org
