| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GUCY2D |
| Gene ID: | 3000 |
| Uniprot ID: | GUC2D_HUMAN |
| Immunogen Region: | 52-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 52-350 of human GUCY2D (NP_000171.1). |
| Immunogen Sequence: | AVFTVGVLGPWACDPIFSRA RPDLAARLAAARLNRDPGLA GGPRFEVALLPEPCRTPGSL GAVSSALARVSGLVGPVNPA ACRPAELLAEEAGIALVPWG CPWTQAEGTTAPAVTPAADA LYALLRAFGWARVALVTAPQ DLWVEAGRSLSTALRARGLP VASVTSMEPLDLSGAREALR KVRDGPRVTAVIMVMHSVLL GGEEQRYLLEAAEELGLTDG SLVFLPFDTIHYALSPGPE |
| Tissue Specificity | Retina. |
| Function | Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Protein Name | Retinal Guanylyl Cyclase 1Retgc-1Cg-EGuanylate Cyclase 2d - RetinalRod Outer Segment Membrane Guanylate CyclaseRos-Gc |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Photoreceptor Outer Segment MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Retinal Guanylyl Cyclase 1 antibodyAnti-Retgc-1 antibodyAnti-Cg-E antibodyAnti-Guanylate Cyclase 2d - Retinal antibodyAnti-Rod Outer Segment Membrane Guanylate Cyclase antibodyAnti-Ros-Gc antibodyAnti-GUCY2D antibodyAnti-CORD6 antibodyAnti-GUC1A4 antibodyAnti-GUC2D antibodyAnti-RETGC antibodyAnti-RETGC1 antibody |
Information sourced from Uniprot.org