| Tissue Specificity | In the retina, it is expressed in rod and cone photoreceptors. |
| Function | Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor light response and recovery of response in bright light. |
| Protein Name | Guanylyl Cyclase-Activating Protein 1Gcap 1Guanylate Cyclase Activator 1a |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | MembraneLipid-AnchorPhotoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentPresent At Higher Levels In Cone Than In Rod Outer SegmentsSubcellular Location Is Not Affected By Light Or Dark Conditions |
| Alternative Antibody Names | Anti-Guanylyl Cyclase-Activating Protein 1 antibodyAnti-Gcap 1 antibodyAnti-Guanylate Cyclase Activator 1a antibodyAnti-GUCA1A antibodyAnti-C6orf131 antibodyAnti-GCAP antibodyAnti-GCAP1 antibodyAnti-GUCA1 antibody |
Information sourced from Uniprot.org
