| Post Translational Modifications | Sumoylation regulates its subcellular location. Sumoylation at Lys-45 and Lys-71 regulates the shuttling between the cytoplasm and the nucleus. Sumoylation at Lys-71 is required for interaction with TBL1X. Sumoylated at Lys-45 and Lys-71 in mitochondrion. Desumoylation by SENP1 leads to relocation from the mitochondria to the nucleus. Ubiquitinated at the C-terminus by SIAH2.leading to its degradation by the proteasome. Interaction with TBL1X and methylation at Arg-323 protect GPS2 against ubiquitination and degradation. Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at Arg-323 protects from degradation by the proteasome. |
| Function | Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination. In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation. Promotes cholesterol efflux by acting as a transcription coactivator. Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways. Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes. Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13. Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG. Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor. Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation. In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways. In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway.acts by repressing UBE2N/Ubc13 activity. In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT. Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Protein Name | G Protein Pathway Suppressor 2Gps-2 |
| Database Links | Reactome: R-MMU-3214815Reactome: -MMU-9029569 |
| Cellular Localisation | NucleusMitochondrionCytoplasmCytosolSumoylation Regulates The Subcellular LocationRelocates From The Mitochondria To The Nucleus Following DesumoylationLeading To Mediate Mitochondrial Stress Response |
| Alternative Antibody Names | Anti-G Protein Pathway Suppressor 2 antibodyAnti-Gps-2 antibodyAnti-Gps2 antibody |
Information sourced from Uniprot.org
