| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Melatonin-related receptor (301-350 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR50 |
| Gene ID: |
9248 |
| Uniprot ID: |
MTR1L_HUMAN |
| Immunogen Region: |
301-350 aa |
| Specificity: |
GPR50 Polyclonal Antibody detects endogenous levels of GPR50 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human MTR1L at the amino acid range 301-350 |
| Post Translational Modifications | Cleaved by CAPN1 in a calcium-dependent manner. |
| Function | G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration. C-terminal domain: Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation. |
| Protein Name | Melatonin-Related ReceptorG Protein-Coupled Receptor 50H9 Cleaved Into - C-Terminal Domain |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic DensityC-Terminal Domain: Nucleus |
| Alternative Antibody Names | Anti-Melatonin-Related Receptor antibodyAnti-G Protein-Coupled Receptor 50 antibodyAnti-H9 Cleaved Into - C-Terminal Domain antibodyAnti-GPR50 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
