| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR34 |
| Gene ID: | 2857 |
| Uniprot ID: | GPR34_HUMAN |
| Immunogen Region: | 300-381 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300-381 of human GPR34 (NP_005291.1). |
| Immunogen Sequence: | YWKEIVHKTNEIMLVLSSFN SCLDPVMYFLMSSNIRKIMC QLLFRRFQGEPSRSESTSEF KPGYSLHDTSVAVKIQSSSK ST |
| Tissue Specificity | Broadly expressed. Highly expressed on mast cells. |
| Function | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis. |
| Protein Name | Probable G-Protein Coupled Receptor 34 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 34 antibodyAnti-GPR34 antibody |
Information sourced from Uniprot.org