| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPIHBP1 (50-151) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPIHBP1 |
| Gene ID: |
338328 |
| Uniprot ID: |
HDBP1_HUMAN |
| Immunogen Region: |
50-151 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2). |
| Immunogen Sequence: |
ETNRLPGGRSRVLLRCYTCK SLPRDERCNLTQNCSHGQTC TTLIAHGNTESGLLTTHSTW CTDSCQPITKTVEGTQVTMT CCQSSLCNVPPWQSSRVQDP TG |
| Post Translational Modifications | Glycosylation of Asn-78 is critical for cell surface localization. Sulfation of a Tyr in the N-terminal acidic region increases the affinity for LPL. |
| Function | Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries. Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. Binds chylomicrons and phospholipid particles that contain APOA5. Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. |
| Protein Name | Glycosylphosphatidylinositol-Anchored High Density Lipoprotein-Binding Protein 1Gpi-Hbp1Gpi-Anchored Hdl-Binding Protein 1High Density Lipoprotein-Binding Protein 1 |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-8963889Reactome: R-HSA-8963901Reactome: R-HSA-975634 |
| Cellular Localisation | Apical Cell MembraneLipid-AnchorGpi-AnchorBasolateral Cell MembraneCell Membrane |
| Alternative Antibody Names | Anti-Glycosylphosphatidylinositol-Anchored High Density Lipoprotein-Binding Protein 1 antibodyAnti-Gpi-Hbp1 antibodyAnti-Gpi-Anchored Hdl-Binding Protein 1 antibodyAnti-High Density Lipoprotein-Binding Protein 1 antibodyAnti-GPIHBP1 antibodyAnti-HBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
