| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade. |
| Protein Name | Guanine Nucleotide-Binding Protein Subunit Alpha-12G Alpha-12G-Protein Subunit Alpha-12 |
| Database Links | Reactome: R-HSA-416482Reactome: R-HSA-456926 |
| Cellular Localisation | Cell MembraneLipid-AnchorLateral Cell MembraneCytoplasmCdh1 Enhances Cell Membrane Localization |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein Subunit Alpha-12 antibodyAnti-G Alpha-12 antibodyAnti-G-Protein Subunit Alpha-12 antibodyAnti-GNA12 antibody |
Information sourced from Uniprot.org
