Western blot of rat spinal cord lysate (SC) showing specific immunolabeling of the ~48 kDa Alpha 1-and Alpha 2-subunits of the glycine receptor. Immunolabeling was absent from a rat hippocampal lysate (H) , as the glycine receptor is not expressed in the hippocampus.

Anti-GLRA1 antibody (N-Term) (STJA0003667)

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STJA0003667-200
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Glycine Receptor (N-Term) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilized
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Glra1
Gene ID: 25674
Uniprot ID: GLRA1_RAT
Immunogen Region: N-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
Tissue Specificity Detected in spinal cord (at protein level). Detected in spinal cord and brain stem.
Function Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition.heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.
Protein Name Glycine Receptor Subunit Alpha-1
Glycine Receptor 48 Kda Subunit
Glycine Receptor Strychnine-Binding Subunit
Database Links Reactome: R-RNO-112314
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Synapse
Perikaryon
Cell Projection
Dendrite
Cell Membrane
Alternative Antibody Names Anti-Glycine Receptor Subunit Alpha-1 antibody
Anti-Glycine Receptor 48 Kda Subunit antibody
Anti-Glycine Receptor Strychnine-Binding Subunit antibody
Anti-Glra1 antibody
Anti-Glyr antibody

Information sourced from Uniprot.org

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