| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GHRL (1-117) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GHRL |
| Gene ID: |
51738 |
| Uniprot ID: |
GHRL_HUMAN |
| Immunogen Region: |
1-117 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human GHRL (NP_057446.1). |
| Immunogen Sequence: |
MPSPGTVCSLLLLGMLWLDL AMAGSSFLSPEHQRVQQRKE SKKPPAKLQPRALAGWLRPE DGGQAEGAEDELEVRFNAPF DVGIKLSGVQYQQHSQALGK FLQDILWEEAKEAPADK |
| Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy. |
| Post Translational Modifications | O-octanoylated by GOAT/MBOAT4. O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Also O-acetylated and O-butyrylated on Ser-26 to minor levels. Amidation of Leu-98 is essential for obestatin activity. |
| Function | Ghrelin-27: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Ghrelin-28: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Protein Name | Appetite-Regulating HormoneGrowth Hormone SecretagogueGrowth Hormone-Releasing PeptideMotilin-Related PeptideProtein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28Ghrelin - Obestatin |
| Database Links | Reactome: R-HSA-375276 Q9UBU3-1Reactome: R-HSA-416476 Q9UBU3-1Reactome: R-HSA-422085 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Appetite-Regulating Hormone antibodyAnti-Growth Hormone Secretagogue antibodyAnti-Growth Hormone-Releasing Peptide antibodyAnti-Motilin-Related Peptide antibodyAnti-Protein M46 Cleaved Into - Ghrelin-27 - Ghrelin-28 antibodyAnti-Ghrelin - Obestatin antibodyAnti-GHRL antibodyAnti-MTLRP antibodyAnti-UNQ524 antibodyAnti-PRO1066 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
