| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. Ubiquitinated. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network. |
| Protein Name | Adp-Ribosylation Factor-Binding Protein Gga1Gamma-Adaptin-Related Protein 1Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 |
| Database Links | Reactome: R-HSA-8854214Reactome: R-HSA-977225 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinEndosome MembraneEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Binding Protein Gga1 antibodyAnti-Gamma-Adaptin-Related Protein 1 antibodyAnti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 1 antibodyAnti-GGA1 antibody |
Information sourced from Uniprot.org
