| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-FAD-linked sulfhydryl oxidase ALR (51-100 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GFER |
| Gene ID: | 2671 |
| Uniprot ID: | ALR_HUMAN |
| Immunogen Region: | 51-100 aa |
| Specificity: | ALR Polyclonal Antibody detects endogenous levels of ALR protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human GFER at the amino acid range 51-100 |
| Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
| Protein Name | Fad-Linked Sulfhydryl Oxidase AlrAugmenter Of Liver RegenerationHerv1Hepatopoietin |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Isoform 1: Mitochondrion Intermembrane SpaceMitochondrionIsoform 2: CytoplasmSecreted |
| Alternative Antibody Names | Anti-Fad-Linked Sulfhydryl Oxidase Alr antibodyAnti-Augmenter Of Liver Regeneration antibodyAnti-Herv1 antibodyAnti-Hepatopoietin antibodyAnti-GFER antibodyAnti-ALR antibodyAnti-HERV1 antibodyAnti-HPO antibody |
Information sourced from Uniprot.org