| Tissue Specificity | Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level). |
| Function | Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
| Protein Name | Growth/Differentiation Factor 5Gdf-5Bone Morphogenetic Protein 14Bmp-14Cartilage-Derived Morphogenetic Protein 1Cdmp-1Lipopolysaccharide-Associated Protein 4Lap-4Lps-Associated Protein 4Radotermin |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedCell Membrane |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 5 antibodyAnti-Gdf-5 antibodyAnti-Bone Morphogenetic Protein 14 antibodyAnti-Bmp-14 antibodyAnti-Cartilage-Derived Morphogenetic Protein 1 antibodyAnti-Cdmp-1 antibodyAnti-Lipopolysaccharide-Associated Protein 4 antibodyAnti-Lap-4 antibodyAnti-Lps-Associated Protein 4 antibodyAnti-Radotermin antibodyAnti-GDF5 antibodyAnti-BMP14 antibodyAnti-CDMP1 antibody |
Information sourced from Uniprot.org
