Western blot analysis of extracts of various cell lines, using GABRR2 antibody (STJ112150) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-GABRR2 antibody (350-450) (STJ112150)

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STJ112150
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GABRR2
Gene ID: 2570
Uniprot ID: GBRR2_HUMAN
Immunogen Region: 350-450
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human GABRR2 (NP_002034.3).
Immunogen Sequence: TVQERKERKLREKFPCMCGM LHSKTMMLDGSYSESEANSL AGYPRSHILTEEERQDKIVV HLGLSGEANAARKKGLLKGQ TGFRIFQNTHAIDKYSRLIF P
Function Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces. When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission. Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum. Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Rho-2
Gaba(A Receptor Subunit Rho-2
Gabaar Subunit Rho-2
Gaba(C Receptor
Database Links Reactome: R-HSA-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Rho-2 antibody
Anti-Gaba(A Receptor Subunit Rho-2 antibody
Anti-Gabaar Subunit Rho-2 antibody
Anti-Gaba(C Receptor antibody
Anti-GABRR2 antibody

Information sourced from Uniprot.org

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