| Tissue Specificity | Expressed in lung, digestive tract, gall bladder, placenta, kidney, uterus and brain. Not detected in spleen, heart, muscle, liver and pancreas. |
| Function | Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation. Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development. Isoform 1: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. Isoform 4: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. Isoform 5: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 10Fucosyltransferase XFuc-TxFuct-XGalactoside 3-L-Fucosyltransferase 10Fucosyltransferase 10 |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneIsoform 4: Golgi ApparatusLysosomeIsoform 5: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 10 antibodyAnti-Fucosyltransferase X antibodyAnti-Fuc-Tx antibodyAnti-Fuct-X antibodyAnti-Galactoside 3-L-Fucosyltransferase 10 antibodyAnti-Fucosyltransferase 10 antibodyAnti-FUT10 antibody |
Information sourced from Uniprot.org
