| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-FPRL1 (13-26) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
FPR2 |
| Gene ID: |
2358 |
| Uniprot ID: |
FPR2_HUMAN |
| Immunogen Region: |
13-26 |
| Accession Number: |
NP_001453.1 |
| Specificity: |
Reported variants represent identical protein: NP_001005738.1 and NP_001453.1. |
| Immunogen Sequence: |
EEVSYESAGYTVLR |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin. |
| Protein Name | N-Formyl Peptide Receptor 2Fmlp-Related Receptor IFmlp-R-IFormyl Peptide Receptor-Like 1Hm63Lipoxin A4 ReceptorLxa4 ReceptorRfp |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAssociates With Amyloid-Beta Protein 42Product Of AppAt The Cell Surface And The Complex Is Then Rapidly InternalizedAlso Internalized In The Presence Of Humanin |
| Alternative Antibody Names | Anti-N-Formyl Peptide Receptor 2 antibodyAnti-Fmlp-Related Receptor I antibodyAnti-Fmlp-R-I antibodyAnti-Formyl Peptide Receptor-Like 1 antibodyAnti-Hm63 antibodyAnti-Lipoxin A4 Receptor antibodyAnti-Lxa4 Receptor antibodyAnti-Rfp antibodyAnti-FPR2 antibodyAnti-FPRH1 antibodyAnti-FPRL1 antibodyAnti-LXA4R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
