Host: | Goat |
Applications: | Pep-ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-FPRL1 (13-26) is suitable for use in ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000. WB: Preliminary testing showed a band at approx 40kDa in Human Heart and approx. 37-38kDa in Human Spleen lysate after 1µg/ml antibody staining (calculated MW of 39.0kDa according to NP_00 |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | FPR2 |
Gene ID: | 2358 |
Uniprot ID: | FPR2_HUMAN |
Immunogen Region: | 13-26 |
Accession Number: | NP_001453.1 |
Specificity: | Reported variants represent identical protein: NP_001005738.1 and NP_001453.1. |
Immunogen Sequence: | EEVSYESAGYTVLR |
Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin. |
Protein Name | N-Formyl Peptide Receptor 2 Fmlp-Related Receptor I Fmlp-R-I Formyl Peptide Receptor-Like 1 Hm63 Lipoxin A4 Receptor Lxa4 Receptor Rfp |
Database Links | Reactome: R-HSA-416476 Reactome: R-HSA-418594 Reactome: R-HSA-444473 Reactome: R-HSA-6798695 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Associates With Amyloid-Beta Protein 42 Product Of App At The Cell Surface And The Complex Is Then Rapidly Internalized Also Internalized In The Presence Of Humanin |
Alternative Antibody Names | Anti-N-Formyl Peptide Receptor 2 antibody Anti-Fmlp-Related Receptor I antibody Anti-Fmlp-R-I antibody Anti-Formyl Peptide Receptor-Like 1 antibody Anti-Hm63 antibody Anti-Lipoxin A4 Receptor antibody Anti-Lxa4 Receptor antibody Anti-Rfp antibody Anti-FPR2 antibody Anti-FPRH1 antibody Anti-FPRL1 antibody Anti-LXA4R antibody |
Information sourced from Uniprot.org